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Molecular Depot Lipid A (E. coli) Highly Pure Compound MDP0891
Lipid A (E. coli) is a highly pure fundamental structural component of lipopolysaccharides (LPS). This product has been used as Lipopolysaccharides (LPS) binding experiments. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.
Catalog number: MDP0891
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.1 mg
Molecular Weight or Concentration: 1798.4 g/mol
Supplied as: Neat
Applications: Lipopolysaccharides (LPS) binding experiments
Storage: -20°C
Keywords: Lipid A (Escherichia coli)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
Indication for Use: This product is for Research Use Only. This product is NOT for human or animal use.
References:
1: Gao J, Guo Z. Progress in the synthesis and biological evaluation of lipid A
and its derivatives. Med Res Rev. 2018 Mar;38(2):556-601.
2: Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D’Errico G,
Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-
Santamaría S. Chemistry of lipid A: at the heart of innate immunity. Chemistry.
2015 Jan 7;21(2):500-19.
3: Wang X, Quinn PJ, Yan A. Kdo2 -lipid A: structural diversity and impact on
immunopharmacology. Biol Rev Camb Philos Soc. 2015 May;90(2):408-27.
4: Verpalen ECJM, Brouwer AJ, Boons GJ. Synthesis of monophosphoryl lipid A
using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr Res. 2020
Dec;498:108152.
5: Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity
relationships of the lipid a family of glycolipids. Curr Opin Chem Biol. 2017
Oct;40:127-137.
6: Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Lipid A structural modifications
in extreme conditions and identification of unique modifying enzymes to define
the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta
Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450.
7: Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is
anticorrelated with lipid a leaflet affinity. PLoS One. 2020 Nov
30;15(11):e0242907.
8: Fujimoto Y, Adachi Y, Akamatsu M, Fukase Y, Kataoka M, Suda Y, Fukase K,
Kusumoto S. Synthesis of lipid A and its analogues for investigation of the
structural basis for their bioactivity. J Endotoxin Res. 2005;11(6):341-7.
9: Di Lorenzo F, Crisafi F, La Cono V, Yakimov MM, Molinaro A, Silipo A. The
Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from
Antarctic Environments. Mar Drugs. 2020 Nov 26;18(12):592.
10: Pallach M, Di Lorenzo F, Duda KA, Le Pennec G, Molinaro A, Silipo A. The
Lipid A Structure from the Marine Sponge Symbiont Endozoicomonas sp. HEX 311.
Chembiochem. 2019 Jan 18;20(2):230-236.
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