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Molecular Depot Human CARD18 Protein B2011695
Human CARD18 Protein is a high quality recombinant human CARD18 protein His tagged and expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.
Human CARD18 Protein
Catalog number:B2011695
Lot number:Batch Dependent
Expiration Date:Batch dependent
Amount:50 µg
Molecular Weight or Concentration:500 µg/mL
Supplied as:Solution
Applications:molecular tool for various biochemical applications
Storage:-20 °C
Keywords:pseudo-ICE protein, CARD-18, Caspase recruitment domain-containing protein 18 protein, ICEBERG protein, CARD18, CARD 18, CARD-18 protein, UNQ5804 protein, CARD 18 protein
Grade:Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Aral K, Berdeli E, Cooper PR, Milward MR, Kapila Y, Karadede Ünal B, Aral CA, Berdeli A. Differential expression of inflammasome regulatory transcripts in periodontal disease J Periodontol. 2020 May;91(5):606-616.
2: Qin H, Jin J, Fischer H, Mildner M, Gschwandtner M, Mlitz V, Eckhart L, Tschachler E. The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus J Dermatol Sci. 2017 Aug;87(2):176-182.
3: Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism Nat Struct Mol Biol. 2016 May;23(5):416-25.
4: Göblös A, Danis J, Vas K, Bata-Csörgő Z, Kemény L, Széll M. Keratinocytes express functional CARD18, a negative regulator of inflammasome activation, and its altered expression in psoriasis may contribute to disease pathogenesis Mol Immunol. 2016 May;73:10-8.
5: Green DR, Melino G. ICE heats up Cell Death Differ. 2001 Jun;8(6):549-50.
6: Mahakur S, Saikia B, Minz M, Minz RW, Nada R, Anand S, Sharma A, Jha V, Joshi N, Goel L, Arora A, Joshi K. Allo-specific immune response profiles indicative of acute rejection in kidney allografts using an in vitro lymphocyte culture-based model Clin Exp Nephrol. 2018 Apr;22(2):465-473.
7: Tan C, Liu S, Xiang Z. [The expression of CARD18 in apoptin-transfected gastric cancer cells and gastric adenocarcinoma tissues] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):858-61.
8: Wright CM, Savarimuthu Francis SM, Tan ME, Martins MU, Winterford C, Davidson MR, Duhig EE, Clarke BE, Hayward NK, Yang IA, Bowman RV, Fong KM. MS4A1 dysregulation in asbestos-related lung squamous cell carcinoma is due to CD20 stromal lymphocyte expression PLoS One. 2012;7(4):e34943.
9: Johansson Å, Eriksson N, Becker RC, Storey RF, Himmelmann A, Hagström E, Varenhorst C, Axelsson T, Barratt BJ, James SK, Katus HA, Steg PG, Syvänen AC, Wallentin L, Siegbahn A; PLATO Investigators. NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients With Acute Coronary Syndromes: Genome-Wide Association Study in the PLATelet inhibition and patient Outcomes Trial (PLATO) Circ Cardiovasc Genet. 2015 Jun;8(3):498-506.
10: da Cunha JP, Galante PA, de Souza SJ. Different evolutionary strategies for the origin of caspase-1 inhibitors J Mol Evol. 2008 Jun;66(6):591-7.
All returns must be authorized by Spectra Services in order to insure proper credit and must be requested within 30 days of purchase. All returns are subject to a minimum 15% restocking charge. For returns not due to error on behalf of Spectra Services, the customer is responsible for all transportation fees related to the returned product. To ensure proper credit, each product return must include the following information:
- Customer name and address
- Purchase order number
- Spectra Services shipping order number
- Date of invoice
- Item number of returned item(s)
- Spectra Services return authorization number (RMA)
- Reason for return
Non-Returnable Goods
Unfortunately, Spectra Services is unable to accept the following returns at this time:
- Products not in completely resalable condition (including products with damaged, missing, or defaced labeling or packaging
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- Laboratory apparatus or instruments that have been used or are without the original packaging, labeling and operating manuals
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Spectra Services reserves the right to review this policy on a case-by-case basis.
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Upon receipt of the pre-owned product(s), the customer has one week to evaluate the product to ensure it meets their expectations. If for some reason the customer decides to return the product, they may do so at any point during those seven (7) days for a full refund. No restocking fee will be assessed, however, the customer is responsible for the return shipping costs. Full credit will be issued upon receipt and inspection of the item(s) to ensure equipment was returned in the same condition it was initially shipped out in.
Important Information
All exchanges and returns require the completion of a Return Merchandise Authorization (RMA) form. Once completed, please return the merchandise immediately as the RMA number is only active for ten (10) days from the date of issuance.
Charges associated with returning items are the responsibility of the customer unless the item(s) arrived defective, damaged, or incorrect.
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