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Molecular Depot Myristolated PKCz Pseudosubstrate ZIP Scrambled B2011210
Myristolated PKCz Pseudosubstrate ZIP Scrambled is a high quality myristoylated peptide for the pseudosubstrate PKC Zeta with scrambled ZIP. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.
Myristolated PKCz Pseudosubstrate ZIP Scrambled
Catalog number:B2011210
Lot number:Batch Dependent
Expiration Date:Batch dependent
Amount:1 mg
Molecular Weight or Concentration:1928.5
Supplied as:Lyophilized
Applications:molecular tool for various biochemical applications
Storage:-20 °C
Keywords:Myristolated PKC Zeta Pseudosubstrate ZIP Scrambled
Grade:Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Lim S, Choi JW, Kim HS, Kim YH, Yea K, Heo K, Kim JH, Kim SH, Song M, Kim JI, Ryu SH, Suh PG. A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity Life Sci. 2008 Mar 26;82(13-14):733-40.
2: Lee-Rivera I, López E, Alvarez-Arce A, López-Colomé AM. The PKC-ζ pseudosubstrate peptide induces glutamate release from retinal pigment epithelium cells through kinase- independent activation of Best1 Life Sci. 2021 Jan 15;265:118860.
3: Eichholtz T, de Bont DB, de Widt J, Liskamp RM, Ploegh HL. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor J Biol Chem. 1993 Jan 25;268(3):1982-6.
4: Verhoeven AJ, Leusen JH, Kessels GC, Hilarius PM, de Bont DB, Liskamp RM. Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C J Biol Chem. 1993 Sep 5;268(25):18593-8.
5: Cao YJ, Li JY, Wang PX, Lin ZR, Yu WJ, Zhang JG, Lu J, Liu PQ. PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling Front Pharmacol. 2022 Feb 14;13:798436.
6: Harris TE, Persaud SJ, Saermark T, Jones PM. A myristoylated pseudosubstrate peptide inhibitor of protein kinase C: effects on glucose- and carbachol-induced insulin secretion Mol Cell Endocrinol. 1996 Aug 9;121(2):133-41.
7: Harishchandran A, Nagaraj R. Interaction of a pseudosubstrate peptide of protein kinase C and its myristoylated form with lipid vesicles: only the myristoylated form translocates into the lipid bilayer Biochim Biophys Acta. 2005 Jul 30;1713(2):73-82.
8: Bergman PJ, Gravitt KR, Ward NE, Beltran P, Gupta KP, O’Brian CA. Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism Invest New Drugs. 1997;15(4):311-8.
9: Gupta KP, Ward NE, Gravitt KR, Bergman PJ, O’Brian CA. Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide J Biol Chem. 1996 Jan 26;271(4):2102-11.
10: Bergman PJ, Gravitt KR, O’Brian CA. An N-myristoylated protein kinase C-alpha pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate Cancer Chemother Pharmacol. 1997;40(5):453-6.
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