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Molecular Depot Sodium taurodeoxycholate (Highly Pure) B2010638
Sodium taurodeoxycholate (Highly Pure) is a highly pure bile salt that acts as an anionic detergent. This product has been used as molecular tool in the study of various metabolic systems. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.
Sodium taurodeoxycholate (Highly Pure)
Catalog number:B2010638
Lot number:Batch Dependent
Expiration Date:Batch dependent
Amount:1 g
Molecular Weight or Concentration:521.69 g/mol
Supplied as:Powder
Applications:molecular tool in the study of various metabolic systems
Storage:RT
Keywords:2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate
Grade:Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Paganoni S, Macklin EA, Hendrix S, Berry JD, Elliott MA, Maiser S, Karam C,
Caress JB, Owegi MA, Quick A, Wymer J, Goutman SA, Heitzman D, Heiman-Patterson
T, Jackson CE, Quinn C, Rothstein JD, Kasarskis EJ, Katz J, Jenkins L, Ladha S,
Miller TM, Scelsa SN, Vu TH, Fournier CN, Glass JD, Johnson KM, Swenson A, Goyal
NA, Pattee GL, Andres PL, Babu S, Chase M, Dagostino D, Dickson SP, Ellison N,
Hall M, Hendrix K, Kittle G, McGovern M, Ostrow J, Pothier L, Randall R, Shefner
JM, Sherman AV, Tustison E, Vigneswaran P, Walker J, Yu H, Chan J, Wittes J,
Cohen J, Klee J, Leslie K, Tanzi RE, Gilbert W, Yeramian PD, Schoenfeld D,
Cudkowicz ME. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic
Lateral Sclerosis. N Engl J Med. 2020 Sep 3;383(10):919-930.
2: Choi HJ, Yun JW, Kim YH, Kwon E, Hyon MK, Kim JY, Che JH, Park JS, Kim HC, Ho
Kim W, Seong SY, Kang BC. Nonclinical toxicology studies with sodium
taurodeoxycholate: acute and subacute toxicity in dogs. Drug Chem Toxicol. 2021
Mar;44(2):161-169.
3: Pardue MT, Allen RS. Neuroprotective strategies for retinal disease. Prog
Retin Eye Res. 2018 Jul;65:50-76.
4: Choi HJ, Yun JW, Kim YH, Kwon E, Hyon MK, Kim JY, Che JH, Ho Kim W, Seong SY,
Kang BC. Evaluation of acute and subacute toxicity of sodium taurodeoxycholate
in rats. Drug Chem Toxicol. 2021 May;44(3):268-276.
5: Kusaczuk M. Tauroursodeoxycholate-Bile Acid with Chaperoning Activity:
Molecular and Cellular Effects and Therapeutic Perspectives. Cells. 2019 Nov
20;8(12):1471.
6: Bhargava P, Smith MD, Mische L, Harrington E, Fitzgerald KC, Martin K, Kim S,
Reyes AA, Gonzalez-Cardona J, Volsko C, Tripathi A, Singh S, Varanasi K, Lord
HN, Meyers K, Taylor M, Gharagozloo M, Sotirchos ES, Nourbakhsh B, Dutta R,
Mowry EM, Waubant E, Calabresi PA. Bile acid metabolism is altered in multiple
sclerosis and supplementation ameliorates neuroinflammation. J Clin Invest. 2020
Jul 1;130(7):3467-3482.
7: Elia AE, Lalli S, Monsurrò MR, Sagnelli A, Taiello AC, Reggiori B, La Bella
V, Tedeschi G, Albanese A. Tauroursodeoxycholic acid in the treatment of
patients with amyotrophic lateral sclerosis. Eur J Neurol. 2016 Jan;23(1):45-52.
doi: 10.1111/ene.12664. Epub 2015 Feb 9. Erratum in: Eur J Neurol. 2017
Apr;24(4):659.
8: Kobayashi T, Suzuki K. A taurodeoxycholate-activated galactosylceramidase in
the murine intestine. J Biol Chem. 1981 Feb 10;256(3):1133-7.
9: Enache M, Toader AM, Neacsu V, Ionita G, Enache MI. Spectroscopic
Investigation of the Interaction of the Anticancer Drug Mitoxantrone with Sodium
Taurodeoxycholate (NaTDC) and Sodium Taurocholate (NaTC) Bile Salts. Molecules.
2017 Jun 28;22(7):1079.
10: Chang S, Kim YH, Kim YJ, Kim YW, Moon S, Lee YY, Jung JS, Kim Y, Jung HE,
Kim TJ, Cheong TC, Moon HJ, Cho JA, Kim HR, Han D, Na Y, Seok SH, Cho NH, Lee
HC, Nam EH, Cho H, Choi M, Minato N, Seong SY. Taurodeoxycholate Increases the
Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front
Immunol. 2018 Sep 18;9:1984.
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