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Molecular Depot BACE Antibody (Affinity Purified) B2010587
BACE Antibody (Affinity Purified) is highly specific to human BACE (beta-Site APP Cleaving Enzyme). This product has been used as molecular tool in the study of BACE. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.
BACE Antibody (Purified)
Catalog number:B2010587
Lot number:Batch Dependent
Expiration Date:Batch dependent
Amount:100 ug
Molecular Weight or Concentration:na
Supplied as:Purified Antibody
Applications:molecular tool in the study of BACE
Storage:-20C
Keywords:ASP2, BACE1, Beta Secretase, beta-Site APP Cleaving Enzyme
Grade:Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Hung SY, Fu WM. Drug candidates in clinical trials for Alzheimer’s disease. J
Biomed Sci. 2017 Jul 19;24(1):47.
2: Siblerud R, Mutter J, Moore E, Naumann J, Walach H. A Hypothesis and Evidence
That Mercury May be an Etiological Factor in Alzheimer’s Disease. Int J Environ
Res Public Health. 2019 Dec 17;16(24):5152.
3: Meier SR, Syvänen S, Hultqvist G, Fang XT, Roshanbin S, Lannfelt L, Neumann
U, Sehlin D. Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in
Alzheimer Transgenic Mice After BACE-1 Inhibition. J Nucl Med. 2018
Dec;59(12):1885-1891.
4: Panza F, Lozupone M, Solfrizzi V, Sardone R, Piccininni C, Dibello V,
Stallone R, Giannelli G, Bellomo A, Greco A, Daniele A, Seripa D, Logroscino G,
Imbimbo BP. BACE inhibitors in clinical development for the treatment of
Alzheimer’s disease. Expert Rev Neurother. 2018 Nov;18(11):847-857.
5: Luo G, Xu H, Huang Y, Mo D, Song L, Jia B, Wang B, Jin Z, Miao Z. Deposition
of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice. Biomed Res
Int. 2016;2016:8380618.
6: Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D,
Tanghe A, Bohrmann B. Combined treatment with a BACE inhibitor and anti-Aβ
antibody gantenerumab enhances amyloid reduction in APPLondon mice. J Neurosci.
2014 Aug 27;34(35):11621-30.
7: Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J,
Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. J Prev Alzheimers Dis.
2020;7(3):146-151.
8: Janssens J, Hermans B, Vandermeeren M, Barale-Thomas E, Borgers M, Willems R,
Meulders G, Wintmolders C, Van den Bulck D, Bottelbergs A, Ver Donck L, Larsen
P, Moechars D, Edwards W, Mercken M, Van Broeck B. Passive immunotherapy with a
novel antibody against 3pE-modified Aβ demonstrates potential for enhanced
efficacy and favorable safety in combination with BACE inhibitor treatment in
plaque-depositing mice. Neurobiol Dis. 2021 Jul;154:105365.
9: Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V.
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can
Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol
Biol. 2018 May 25;430(11):1566-1576.
All returns must be authorized by Spectra Services in order to insure proper credit and must be requested within 30 days of purchase. All returns are subject to a minimum 15% restocking charge. For returns not due to error on behalf of Spectra Services, the customer is responsible for all transportation fees related to the returned product. To ensure proper credit, each product return must include the following information:
- Customer name and address
- Purchase order number
- Spectra Services shipping order number
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- Item number of returned item(s)
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- Reason for return
Non-Returnable Goods
Unfortunately, Spectra Services is unable to accept the following returns at this time:
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- Laboratory apparatus or instruments that have been used or are without the original packaging, labeling and operating manuals
- Refrigerated products or other perishables
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Spectra Services reserves the right to review this policy on a case-by-case basis.
Pre-Owned Products
Upon receipt of the pre-owned product(s), the customer has one week to evaluate the product to ensure it meets their expectations. If for some reason the customer decides to return the product, they may do so at any point during those seven (7) days for a full refund. No restocking fee will be assessed, however, the customer is responsible for the return shipping costs. Full credit will be issued upon receipt and inspection of the item(s) to ensure equipment was returned in the same condition it was initially shipped out in.
Important Information
All exchanges and returns require the completion of a Return Merchandise Authorization (RMA) form. Once completed, please return the merchandise immediately as the RMA number is only active for ten (10) days from the date of issuance.
Charges associated with returning items are the responsibility of the customer unless the item(s) arrived defective, damaged, or incorrect.
Spectra Services highly recommends that return packages be insured for full value and packaged securely to prevent shipping damage.
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