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Molecular Depot Human Insulin-like Growth Factor-Binding Protein 5 B2010281
Human Insulin-like Growth Factor-Binding Protein 5 (Human) is a high quality research product used as highly pure Human Insulin-like Growth Factor-Binding Protein 5 (Human) expressed in CHO cells. This protein acts as a peculiar protein that modulates the action of secreted insulin-like growth factors. It also stimulates osteoblast proliferation. Custom bulk orders of this product are available upon request.
Human Insulin-like Growth Factor-Binding Protein 5
Catalog number:B2010281
Lot number:Batch Dependent
Expiration Date:Batch dependent
Volume/Weight:10 ug
pH:7.4 upon reconstitution
Supplied as:Lyophilized Powder
Appearance:Powder
Applications:highly pure Human Insulin-like Growth Factor-Binding Protein 5 (Human) expressed in CHO cells. This protein acts as a peculiar protein that modulates the action of secreted insulin-like growth factors. It also stimulates osteoblast proliferation.
Storage:-20C
Keywords:rHuIGF-BP5; IBP-5
Grade:Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR,
Arnold S, Bennett DA, Arvanitakis Z. Brain IGFBP-5 modifies the relation of
depressive symptoms to decline in cognition in older persons. J Affect Disord.
2019 May 1;250:313-318.
2: Hwang JR, Cho YJ, Lee Y, Park Y, Han HD, Ahn HJ, Lee JH, Lee JW. The
C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis. Sci
Rep. 2016 Dec 23;6:39334.
3: Su Y, Nishimoto T, Feghali-Bostwick C. IGFBP-5 Promotes Fibrosis
Independently of Its Translocation to the Nucleus and Its Interaction with
Nucleolin and IGF. PLoS One. 2015 Jun 23;10(6):e0130546.
4: Flint DJ, Beattie J, Allan GJ. Modulation of the actions of IGFs by IGFBP-5
in the mammary gland. Horm Metab Res. 2003 Nov-Dec;35(11-12):809-15.
5: DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou
AE, Christou H, Mantzoros C. Placental proteases PAPP-A and PAPP-A2, the binding
proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical
cord blood and associations with birth weight and length. Metabolism. 2019
Nov;100:153959.
6: Mohan S, Farley JR, Baylink DJ. Age-related changes in IGFBP-4 and IGFBP-5
levels in human serum and bone: implications for bone loss with aging. Prog
Growth Factor Res. 1995;6(2-4):465-73.
7: Pan J, Li K, Huang W, Zhang X. MiR-137 inhibited cell proliferation and
migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating
the mTOR/STAT3 signaling. PLoS One. 2017 Oct 10;12(10):e0186245.
8: Mohan S, Baylink DJ. Serum insulin-like growth factor binding protein
(IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases. Endocrine.
1997 Aug;7(1):87-91.
9: Allan GJ, Beattie J, Flint DJ. The role of IGFBP-5 in mammary gland
development and involution. Domest Anim Endocrinol. 2004 Oct;27(3):257-66.
10: Tonner E, Allan G, Shkreta L, Webster J, Whitelaw CB, Flint DJ. Insulin-like
growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell
death and plasminogen activation in the mammary gland. Adv Exp Med Biol.
2000;480:45-53.
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